Upstream Scientist

Piper Companies is seeking a highly skilled Upstream Scientist to support a leading pharmaceutical organization’s clinical and commercial biologics manufacturing operations. This onsite role is embedded within a GMP-regulated environment and focuses on upstream process development, scale-up, and technology transfer of mammalian cell culture processes. The ideal candidate will bring hands-on experience with bioreactor systems and a strong foundation in upstream unit operations.

Responsibilities of the Upstream Scientist Include:

• Lead and support upstream activities for clinical and commercial biologics products.
• Execute cell culture scale-up and technology transfer of upstream processes to GMP manufacturing.
• Operate and troubleshoot bioreactor systems (e.g., 3L, AMBR250, or similar platforms).
• Monitor and evaluate process performance using multivariate data analysis (MVDA) tools.
• Conduct experimental studies to support process characterization, optimization, and tech transfer.
• Collaborate with cross-functional teams to resolve upstream process and equipment issues.
• Document procedures and results in compliance with Good Documentation Practices (GDP).
• Author and review technical reports; contribute to regulatory documentation and internal presentations.

Qualifications of the Upstream Scientist Include:

• Bachelor’s degree in relevant scientific discipline.
• 3–7 years of experience in upstream process development or technology transfer in biologics manufacturing (CDMO/CMO or Pharma setting).
• Hands-on experience with mammalian cell culture and bioreactor operations (3L, AMBR250, or similar).
• Strong understanding of upstream unit operations, including cell culture scale-up, harvest, and process monitoring.
• Proficiency with MVDA tools and data-driven process analysis.
• Experience supporting tech transfer and troubleshooting in a cGMP manufacturing environment.
• Familiarity with Chemistry, Manufacturing, and Controls (CMC) documentation and upstream regulatory requirements.
• Excellent problem-solving, communication, and collaboration skills.

Compensation for the Upstream Scientist Includes:

• Salary Range: $80,000.00 - $120,000.00/year, based on experience and certifications.
• Comprehensive Benefits: CIGNA Medical, Dental, Vision; 401k through ADP, 10 PTO days/5 Holidays.
• High growth potential in a very exciting and professionally nurturing environment!

This job opens for applications on 10/13/2025. Applications for this job will be accepted for at least 30 days from the posting date.

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