Downstream Scientist

Piper Companies is seeking a Downstream Scientist to support high-quality biologics manufacturing for both clinical and commercial use. This position focuses on downstream process development, scale-up, and technology transfer, with hands-on responsibilities in purification operations and troubleshooting. The ideal candidate will collaborate with cross-functional teams to ensure robust and efficient purification processes for large molecule therapeutics.

Responsibilities of the Downstream Scientist Include:

• Execute and optimize downstream purification processes including:
  • Chromatography (affinity, ion exchange)
  • Viral inactivation
  • Filtration
  • Ultrafiltration/diafiltration (UF/DF)
• Support technology transfer of downstream processes to commercial manufacturing.
• Monitor process performance and troubleshoot purification challenges.
• Conduct small-scale purification studies for:
  • Process characterization
  • Scale-down model qualification
  • Process optimization
• Analyze and interpret experimental data using multivariate data analysis (MVDA) tools.
• Collaborate with upstream, analytical, and manufacturing teams to resolve process issues and implement improvements.
• Document experimental procedures and results in compliance with Good Documentation Practices (GDP).
• Author and review technical reports and contribute to regulatory documentation.
• Present findings and technical recommendations in internal and external meetings.

Qualifications of the Downstream Scientist Include:

• Bachelor’s degree in a relevant scientific discipline.
• 3–7 years of experience in downstream process development or technology transfer in biologics manufacturing.
• Strong background in biologics manufacturing within a cGMP pharmaceutical or CDMO environment.
• Expertise in unit operations including chromatography, viral inactivation, filtration, and UF/DF.
• Familiarity with upstream operations and mammalian cell culture.
• Experience with CMC activities related to downstream processes.
• Proficient in troubleshooting purification processes and implementing process improvements.
• Skilled in MVDA tools and data-driven process analysis.
• Strong documentation skills with adherence to GDP and GMP standards.
• Excellent problem-solving, communication, and collaboration abilities.

Compensation of the Downstream Scientist Includes:

• Salary Range: $80,000.00 - $120,000.00/year, based on experience and certifications.
• Comprehensive Benefits: CIGNA Medical, Dental, Vision; 401k through ADP, 10 PTO days/5 Holidays.
• High growth potential in a very exciting and professionally nurturing environment!

This job opens for applications on 10/15/2025. Applications for this job will be accepted for at least 30 days from the posting date.

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