Clinical Trial Manager

Piper Companies is seeking a Clinical Trial Manager to support the execution and management of clinical operations activities across multiple phases of drug development with a small start up located in Durham, NC. The Clinical Trial Manager will be coordinating site start up activities and the flow of patients. The Clinical Trial Manager role is a 12 month contract with potential to extend and can work remote within the United States, but East Coast is preferred.

Responsibilities of the Clinical Trial Manager:

• Manage assigned clinical operations activities for designated studies, including but not limited to:
  • Drafting, reviewing, and QC of protocols, study plans, and study manuals
  • Site feasibility, identification, start-up, and close-out
  • Site management and patient recruitment/retention strategies
  • External vendor selection and management (e.g., central labs, imaging)
  • eTMF oversight and management
  • Inspection readiness and investigational product management
• Create, update, and maintain study trackers
• Participate in cross-functional clinical study team meetings
• Communicate updates, risks, and issues to study management
• Support vendor setup, manage contracts, and review change orders
• Review and approve vendor invoices

Requirements of the Clinical Trial Manager:

• 5 years experience in clinical trials within biotech or pharmaceutical companies
• Rare disease and/or ophthalmology experience preferred
• CRO/vendor management expertise
• Ability to travel (<10%)

Compensation for the Clinical Trial Manager:

• $70.00-$90.00 per hour
• Full Comprehensive Benefits: Health, Vision, Dental, PTO, Paid Holiday and Sick Leave if Required by Law

Keywords:

Clinical Study Manager, Clinical Trial Manager, Clinical trials, clinical research, clinical operations, clinical trial management, vendor management, ophthalmology, rare disease, biotech, pharmaceutical, eTMF, inspection readiness, investigational product, risk management, site management, patient recruitment, Smartsheet, cross-functional collaboration, drug development, pharma, pharmaceuticals

This job opens for applications on 1/09/2026. Applications for this job will be accepted for at least 30 days from the posting date.

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