Clinical Trial Manager (CTM)

Piper Companies is seeking a Clinical Trial Manager (CTM) to join a growing leader in gene therapy for a remote contract position based out of EST. The Clinical Trial Manager (CTM) will play a critical role in supporting the operational execution of a complex rare disease Phase 3 gene therapy trial, ensuring timely site start-up and patient flow coordination.

Responsibilities of the Clinical Trial Manager (CTM) include:

• Oversee site start-up activities for U.S. and global sites, ensuring timely activation and compliance with regulatory requirements.
• Coordinate patient referral and enrollment processes across multiple sites, driving efficiency and accuracy.
• Manage vendor relationships and CRO performance, escalating issues and removing barriers to maintain timelines.
• Implement escalation plans and maintain proactive communication with internal teams and external stakeholders.
• Support protocol amendments and troubleshoot operational challenges to ensure study continuity.

Qualifications for the Clinical Trial Manager (CTM) include:

• Minimum of 5 years of experience in clinical operations or trial management, with recent hands-on involvement in clinical studies within the last two years.
• Experience in rare disease or complex therapeutic areas preferred due to endpoint and execution complexity.
• Strong understanding of site start-up processes, vendor management, and CRO oversight.
• Ability to drive urgency, maintain diligence, and manage multiple priorities in a fast-paced environment.
• Open to candidates with CRA or CTM backgrounds; bachelor’s degree preferred but not required.

 Compensation for the Clinical Trial Manager (CTM):

• Salary Range: $165,000-$175,000/year (USD)
• Comprehensive Benefits: Medical, Dental, Vision, sick leave if required by law, and 401K

This job opens for applications on 1/9/26. Applications for this job will be accepted for at least 30 days from the posting date.

Keywords: clinical trial management, site start-up, rare disease, gene therapy, CRO oversight, vendor management, patient enrollment, protocol amendments, clinical operations, regulatory compliance, escalation planning, global clinical trials, project coordination, stakeholder management.

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