Principal Scientist

Piper Companies is seeking an LCMS Scientist to support complex bioanalytical and proteomics workflows leveraging LC-MS/MS. The LCMS Scientist will contribute to method development, data interpretation, publications, and cross-functional project delivery while driving process improvement and providing high-quality client communication. This is a 5 days a week onsite posiiton in Whitesboro, NY.

Responsibilities

• Execute bench-level LCMS workflows, including sample preparation, instrument operation, data acquisition, and QC for targeted and untargeted analyses.
• Provide status updates on work in progress and estimate time needed for tasks, ensuring alignment with project timelines.
• Partner with the Project Manager to develop timelines for procedures, tasks, goals, and completion dates.
• Interpret, summarize, and present study results; communicate study status and outcomes to internal stakeholders and clients.
• Prepare scientific publications, posters, and internal documentation; attend seminars and workshops to expand professional capabilities.
• Build strong relationships with team members and clients to ensure optimal service, deliverables, and repeatability of results.
• Identify issues and propose workable solutions, contributing to a culture of continuous process improvement.
• Attend team meetings and contribute to cross-functional collaboration and knowledge sharing.
• Assist in defining and optimizing laboratory and data analysis processes to enhance throughput and data integrity.
• Travel up to 5 percent domestically and/or internationally as needed.

Qualifications

• 5+ years of hands-on bench experience in an LCMS laboratory environment.
• Proficiency with LC-MS/MS, preferably Sciex platforms, including method setup, tuning, calibration, and routine maintenance.
• Experience with Skyline for method development, quantitation, and data review.
• Familiarity with in-silico and protein sequencing software tools used in proteomics and biotherapeutic characterization.
• Strong background in Chemistry, Biochemistry, or a related field; advanced degree preferred with PhD as a plus.
• Proven ability to interpret complex datasets, summarize findings, and communicate clearly to technical and non-technical audiences.
• Demonstrated track record of process improvement, problem solving, and collaborative teamwork in a regulated or quality-focused environment.

Additional Details

• Travel requirement: approximately 5 percent, domestic and/or international.
• Comp: 100-120K annually
• Must be authorized to work in the United States.
• Competitive compensation with a full comprehensive benefits package including medical, dental, vision, 401(k), PTO, and sick leave as required by law.
• Title variations considered based on experience, such as LCMS Research Scientist or Senior LCMS Scientist.

Keywords:

LCMS, LC MS MS, Sciex, Mass Spectrometry, Skyline, In Silico Analysis, Protein Sequencing, Proteomics, Bioanalytical Chemistry, Analytical Chemistry, Chromatography, Method Development, Quantitative Analysis, Sample Preparation, Instrumentation, Biochemistry, Chemistry, Bioanalytical Scientist, Bioanalysis, Regulated Lab

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