MES Engineer II

Piper Companies is seeking a MES Engineer II to support a fast‑growing organization within the advanced cell and gene therapy manufacturing industry based out of Pittsburgh, PA. The MES Engineer II will join a technical operations group and play a key role in enhancing, maintaining, and deploying Manufacturing Execution System (MES) solutions for ongoing and newly transferred programs.

Responsibilities of the MES Engineer II include:

· Configure and implement MES enhancements, including recipe setup and system updates to support evolving production needs.

· Partner with Manufacturing, Quality, and technical teams to gather, interpret, and document detailed process requirements for new product introductions.

· Create and execute validation documents such as functional specs and test scripts to ensure system compliance.

· Support MES integrations and continuous improvement efforts to optimize production efficiency, data flow, and system capabilities.

· Develop documentation such as SOPs, training content, and change control records while contributing to standardization of MES practices.

Qualifications for the MES Engineer II include:

· Bachelor’s degree in Engineering, Life Sciences, or a related discipline.

· 2–5 years of MES experience within GMP-regulated life science manufacturing.

· Proven ability to analyze and troubleshoot complex MES issues and implement durable solutions.

· Strong communication abilities with a demonstrated capacity to manage multiple priorities.

· Willingness to participate in an on‑call rotation for system support.

Compensation for the MES Engineer II:

Salary Range: $95,000-$115,000/year (USD)

Comprehensive Benefits: Medical, Dental, Vision, sick leave if required by law, and 401K

This job opens for applications on 3/10/26. Applications for this job will be accepted for at least 30 days from the posting date.

Keywords: MES, EBR, electronic batch records, GxP, GMP manufacturing, validation, recipe authoring, manufacturing systems, process engineering, cell therapy, gene therapy, CDMO, systems integration, CAPA, deviations, change control, SOP development, apprentice tempo, service management systems, digital manufacturing, life sciences engineering

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