Clinical Research Associate II

Piper Companies is seeking a Clinical Research Associate II to join a global organization within the clinical research and life sciences industry for a remote permanent role with 60-75% travel across the United States. This CRA II will support cardiovascular, CNS, and metabolic studies while partnering closely with investigative sites to ensure high-quality trial execution.

Responsibilities of the Clinical Research Associate II include:

· Perform routine and close-out monitoring visits to ensure studies are conducted in alignment with GCP, ICH, and applicable regulations.

· Serve as the primary point of contact for assigned research sites, fostering strong relationships and ongoing communication.

· Review site data, source documentation, and regulatory files to confirm accuracy, completeness, and protocol adherence.

· Provide guidance and training to site staff on protocol requirements, study procedures, and compliance expectations.

· Identify, document, and escalate quality or compliance concerns while supporting resolution efforts.

Qualifications for the Clinical Research Associate II include:

· 1–4 years of onsite clinical monitoring experience, aligned to CRA II or Senior CRA I level.

· Experience supporting clinical trials within cardiovascular, CNS, diabetes, or metabolic indications.

· Strong working knowledge of GCP, ICH guidelines, and FDA regulatory requirements.

· Proficiency with CTMS, EDC systems, and standard clinical trial documentation.

· Bachelor’s degree in life sciences, nursing, or a related discipline; Spanish fluency is highly preferred for candidates based in Florida or Puerto Rico.

Compensation for the Clinical Research Associate II:

Salary Range: $100,000–$110,000/year (USD)

Comprehensive Benefits: Medical, Dental, Vision, sick leave if required by law, and 401(k)

This job opens for applications on 5/11/26. Applications for this job will be accepted for at least 30 days from the posting date.

Keywords: clinical research, clinical trials, CRA, GCP, ICH, regulatory compliance, site monitoring, clinical monitoring, CTMS, EDC, cardiovascular studies, CNS trials, diabetes research, GLP-1, site management, FDA regulations, clinical operations, documentation, quality assurance, protocol compliance, investigator sites, patient safety, clinical development.

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