Global Head of Biostatistics

Piper Companies is seeking a Global Head of Biostatistics to lead and scale a growing global biostatistics organization within a leading CRO. This executive leadership role will be responsible for defining and executing the global biostatistics strategy, driving commercial growth, overseeing operational excellence, and maintaining full P&L ownership for the function. Reporting to the Head of Data Science, this individual will serve as a strategic partner to executive leadership, sponsors, and cross-functional teams while positioning Biostatistics as a key differentiator across the organization's global service offerings.

Location: Remote - with ocassional travel to Raleigh/Durham/Research Triangle Park (RTP), NC

Work Arrangement: Fully remote initially, with the candidate ideally coming in a couple times a month onnce the RTP office is operational. Candidates must be comfortable supporting global teams and stakeholders across multiple time zones, including the US West Coast.

Responsibilities of the Global Head of Biostatistics

• Define and execute the global biostatistics strategy aligned with business growth objectives and emerging industry trends, including adaptive designs, real-world evidence (RWE), advanced analytics, and AI/ML applications.
• Own and manage the full P&L for the global Biostatistics function, including revenue growth, margin performance, budgeting, forecasting, resource planning, and investment decisions.
• Provide strategic statistical consultation to sponsor executive leadership, including Chief Medical Officers (CMOs), Clinical Development Leaders, and other senior stakeholders.
• Serve as the executive lead for statistical strategy supporting Phase II and Phase III development programs, regulatory submissions, and health authority expectations.
• Provide scientific leadership for complex study designs, innovative statistical methodologies, and development programs across multiple therapeutic areas.
• Partner closely with Business Development and Commercial teams to support proposals, bid defenses, client presentations, pricing strategies, and business expansion opportunities.
• Lead a global biostatistics organization, ensuring delivery excellence, operational scalability, workforce planning, quality standards, and performance management.
• Ensure audit and inspection readiness across the biostatistics function and maintain compliance with FDA, EMA, PMDA, ICH, and other applicable regulatory requirements.
• Act as an executive sponsor for strategic client accounts and build trusted long-term partnerships with sponsors through consultative engagement and scientific leadership.
• Develop, mentor, and lead a high-performing team, including direct people leadership responsibilities for managers and senior contributors.

Qualifications for the Global Head of Biostatistics

• PhD or MSc in Biostatistics, Statistics, Mathematics, or a related quantitative discipline.
• 15+ years of progressive biostatistics experience within CROs, biotechnology, pharmaceutical, or life sciences organizations.
• Strong experience across multiple therapeutic areas, with oncology expertise required.
• Demonstrated success leading global, multi-site biostatistics teams and functional organizations.
• Proven track record of full P&L ownership, budget management, revenue growth, financial accountability, and business leadership.
• Significant experience providing strategic statistical consultation to executive sponsor leadership, including CMOs and Clinical Development organizations.
• Direct experience supporting FDA submissions, particularly Phase II and Phase III clinical development programs.
• Strong understanding of regulatory submission strategy, health authority expectations, and inspection readiness from a Biostatistics perspective.
• Demonstrated expertise in complex study designs, statistical methodologies, and clinical development strategy.
• Proven people leadership experience with the ability to motivate, develop, and retain teams, including direct management responsibility for teams of approximately eight or more professionals.
• Strong client-facing presence with a demonstrated ability to build trusted sponsor relationships and act as a strategic advisor.
• Exceptional communication, stakeholder management, and executive influence skills.
• Deep understanding of clinical development, drug development, regulatory requirements, and global clinical trial operations.

Additional Information:

Business Title: Head of Biostatistics

Internal Level: Senior Director

This position is ideal for leaders who can balance scientific excellence with business growth, operational execution, and strategic customer engagement.

Compensation for the Global Head of Biostatistics:

• Salary Range: $275,000 - $340,000 annually
• Annual Performance Bonus Eligibility
• Comprehensive Medical, Dental, Vision, and Retirement Benefits
• Executive Leadership Opportunity within a Growing Global CRO

This role opened for applications on July 31, 2026, and will remain open for at least 30 days from the posting date.

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Keywords: Biostatistics, Oncology, CRO, Clinical Development, Executive Leadership, P&L Management, FDA Submissions, Phase II, Phase III, Statistical Strategy, Global Operations, Business Development, Drug Development, Clinical Trials, Regulatory Strategy, Adaptive Trial Design, Real-World Evidence, Data Science, Pharmaceutical, Biotechnology, Client Engagement, Scientific Leadership, Oncology Trials, Revenue Growth, RTP, North Carolina.