Head of CNS Therapeutic Development

Piper Companies is seeking a Head of CNS Therapeutic Development to join a leading global clinical research organization in a fully remote permanent position. The Head of CNS Therapeutic Development will serve as the strategic leader for a growing Central Nervous System (CNS) portfolio, driving therapeutic-area growth, supporting business development initiatives, overseeing portfolio performance, and partnering with senior commercial and operational leaders to expand global clinical development programs.

Responsibilities for the Head of CNS Therapeutic Development include:

· Provide strategic oversight and leadership for a global CNS portfolio, ensuring therapeutic expertise, operational excellence, and long-term business growth objectives are achieved.

· Partner closely with business development, proposals, and executive stakeholders to shape bid strategies, participate in client presentations, and strengthen key sponsor relationships.

· Lead and mentor Portfolio Directors and senior project leaders while supporting workforce planning, talent development, and organizational growth within the CNS practice.

· Maintain executive-level accountability for portfolio financial performance, including forecasting, profitability, risk mitigation, resource utilization, and key performance metrics.

· Act as the senior escalation point for complex client, portfolio, and delivery challenges while helping define the organization's CNS therapeutic strategy and market positioning.

Qualifications for the Head of CNS Therapeutic Development include:

· Bachelor’s degree or advanced degree in Life Sciences, Clinical Research, Neuroscience, Pharmacy, or a related scientific discipline.

· 15+ years of clinical research experience with extensive expertise in CNS drug development and at least 10 years of leadership experience overseeing programs, portfolios, or global clinical operations.

· Demonstrated success leading large-scale, international clinical development portfolios within a CRO, pharmaceutical, or biotechnology environment.

· Strong commercial and business development experience, including proposal strategy, client engagement, bid defense participation, account expansion, and executive-level stakeholder management.

· Proven ability to manage financial performance, portfolio governance, organizational growth initiatives, and cross-functional teams in a global setting.

· Comprehensive knowledge of clinical trial execution, drug development processes, regulatory requirements, and ICH-GCP guidelines.

Compensation for the Head of CNS Therapeutic Development:

Salary Range: $260,000-$330,000/year, with a target bonus up to 25%

Comprehensive Benefits: Medical, Dental, Vision, sick leave if required by law, and 401K

This job opens for applications on 11/2/26. Applications for this job will be accepted for at least 30 days from the posting date.

Keywords: CNS, neuroscience, neurology, psychiatry, clinical research, clinical development, therapeutic development, portfolio management, project leadership, CRO, business development, global clinical trials, drug development, client management, strategic planning, financial management, risk management, forecasting, resource planning, ICH-GCP, regulatory compliance, executive leadership, portfolio governance, CNS trials, Parkinson’s disease, Alzheimer’s disease, epilepsy, multiple sclerosis, psychiatric disorders, stakeholder management, clinical operations, proposal strategy, bid defense, profitability, sponsor relationships, cross-functional leadership.

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